The WAMS' "1st WORLD DECLARATION of ONCOGENESIS"

In association with JCTR "The Journal of Clinical Trials" 

29-30 October 2016 Paris

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1st World Declaration of Oncogenesis

Holder of the Declaration: WAMS The World Academy of Medical Sciences

"The World Declaration of Oncogenesis" Council (WDOC)
 The World Academy of Medical Sciences (WAMS)

Contrary to the current common belief, in multicellular organisms, malignant neoplasms, including leukemias, in vivo, never arise from single cells. At the WAMS, the World Academy of Medical Sciences, this has been being claimed for more than a decade now, and yet the claim sees three divided groups in today's research medicine in oncology; the first group agrees and accepts it, the second one rejects it firmly claiming that cancer arises from a single cell, and the third is in the middle saying "Cancer arises sometimes from a single cell, and sometimes from a group of cells". And unbelievably, there is currently a fourth group around saying: "We are not sure as before; cancer probably arises from a single cell, then again, it probably arises from a group of cells; so, we don't know for sure which one it is yet."...  We badly need to talk.

The long odyssey of "Oncogenesis", starting from a gene of importance, and going as far as a time of oncotherapy where it enters its almost-fateful all-out apocalyptic showdown, contains hundreds of constituting elements which integrally and multi-dimensionally involve thousands of players along the way. This epic adventure has enough caliber and portfolio to make itself dramatically the most important phenomenon in human body which it belongs to on the level. So much, so far, has been done to understand and know about Oncogenesis. Enormous amount of work, study and research.  And so much's on the way; we are restlessly doing everything we can to understand it to the utmost of its frontiers. But if we're having problem today understanding the very starting point of the endless dimensions of oncogenetic concatenation with gross uncertainty still asking ourselves whether it arises from a single cell or from a group of cells, we then have a grave problem there with our ways of scientific approach and weighing, and with our sequent appraisement and reckoning; this is a long way to hit. And therefore we need to talk.

If we go fortunate enough to reduce those four "single cell origin" groups to one, hundreds of research laboratories and units around the world would get closed down overnight. But they will not let that happen because multi-fold self-interest sees those hundreds of elements of oncogenesis as assets and its thousands of players as commodities. And as this goes on, oncology itself gets doomed to remain the most commercialized territory of Medicine. Commercial part is inevitably one of the essentials, but we do not have to provide it with more and more cancer patients every single day in tripling, quadrupling numbers.

Oncogenesis, filled with many unsolved mysteries, in itself gets riddled by so many controversies of scientific approach, exploration and research.  In each country, even in each region of a country and even at different research centers and medical centers in the same region of a country, the frontiers of Oncological study and work are set quite variably. And they are regrettably set "as is". And the addition of the classic issue of self-interest to that, makes the future of Oncology dreadful to imagine. Oncogenesis otherwise could have been better undersood, better interpreted and better handled, and more accomodative and comprehendible with cleaner and clearer avenues and with more open gates to untrammelled work, smooth theories and straight discoveries which all would be in the interest of the cancer patient as well as the science itself and in the interest of Mankind.

As it occupies an exclusive seat among all well-known phenomena in human body, and not really deserving the bitter realities we talk here, Oncogenesis is entitled to a "World Declaration" which in fact should have been made decades ago. The Declaration of Oncogenesis is the "Constitution of Oncogenesis" and the "Charter of Universal Oncology". It defines what is good and beneficial in the science and practice of Oncology, and what is not, what is right and what's wrong, what is vital and vitally important and what's not, what is essential, what is appropriate and just and what is not, what is redundant and unnecessary, what is obsolete, what is up-to-date, what is favorable and what is unfavorable, and what is ethical and what is not. 

At the two-part "World Declaration of Oncogenesis" conference in Paris and London in 2014, Declaration of Oncogenesis will open a huge presentation and debate which will be involving new multi-dimensional and integral series of Oncology discussions which involve: 

- Reviews and debated topics, subjects and cases in the current knowledge in Oncogenesis and Oncology.
- Challenges in current knowledge.
- Disclosure and presentation of new seminal studies and research lines.
- Discussions of new topics, theories, subjects and cases.
- Disclosure and presentation of new theories, opinions and discoveries.
- 300+ Subjects and sub-subjects, numbered as Declaration articles from the cellular origin of Oncogenesis to the practice of Oncotherapy, to be reviewed, discussed, debated and concluded on.
- 100+ New, vital, rule-changing and rule-establishing fundamental theories and seminal articles and research lines to be introduced and discussed.  

At the congress, an elected International Executive Joint Council of the "World Declaration of Oncogenesis" The World Declaration of Oncogenesis Council (WDOC) and a committee for each Oncogenetic and Oncologic subfield/subject (e.g. Molecular Oncology, Tumor Cell Biology, Immunobiology, Metastasis, Cancer Stem Cells, Signal Transduction, etc.) will be established. While the elected subcommittees decide on their individual related subjects, the International Executive joint panel of the World Declaration of Oncogenesis, WDO Council (WDOC) reviews, discusses, decides and concludes on major, crucial and determining subjects and issues of Oncogenesis and Oncology.

In unison and collaboration with national and international medical institutions (Medical Colleges and Faculties, Medical Organizations, Oncology Research Institutions and Laboratories, etc.) as well as related governmental bodies, departments, agencies and units of all the countries, the World Declaration of Oncogenesis systematically arranges comprehensive collection of scientific and professional issues, topics and subjects, and rules and concensuses in Oncogenesis and in the field and practice of clinical and research Oncology, and systematizes and arranges collections of professional knowledge of comprehensive and referential value at practical and scientific levels, as well as regulations and rules of procedures or conducts in the fields of clinical and research Oncology involving all the research and clinical subfields of molecular and medical Oncology into a constitutional code of Oncogenesis and a charter of Oncology which will be consisting of numbered and coded sections, chapters and articles, and be printed and distributed in book form and in multimedia and web medium formats.

For the good of the patient, for the good of the World and the Science of Medicine, the World Declaration of Oncogenesis will meticulously be reviewed and updated at the World Declaration of Oncogenesis (WDO) congresses annually. The articles of the declaration will be officially endorsed, recorded and registered along with their officially approved-proved-determined writers, originators, owners, claimants and other related and dedicated individuals, groups and institutions most of whom will also be mentioned in the articles as claimants and declarants. They will also so be recorded in the official archives of the declaration. Unchanged or unrevised records and registrations will officially be transferred as they are to the following year's declaration.

The World Declaration of Oncogenesis, is, so to say, the constitution of "Oncogenesis"; it is an essential "Official Reference" source in book, e-book and multimedia web medium forms and formats which will be used by all medical and medicine-related professionals as a reference book, referential textbook, and as a professional guidebook. In scientific literary work, research and studies, medical, medicine-related and paramedical, referrals and citations can be made much easily in terms of classified and cumulative referential and citation needs: Just citing, for instance, "ONC-Article1398-28" at the bottom of a published work as reference may be equal to pages of individual citations related to one subject as this Declaration article may contain dozens of published materials on the same subject. It may also be referred to by the Public, as well as official/governmental bodies, departments and agencies and authorities; in a juidical matter or court case, for instance, any article of the Declaration, admissible, may be referred to and used, as officially as that of the law books and Constitution of the country, eliminating or minimizing the necessity of long expert witness work and testimonies.


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